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KMID : 0644120080210020152
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Journal of Oriental Gynecology
2008 Volume.21 No. 2 p.152 ~ p.165
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Anti-inflammatory Effect of Cheukbaekjurpihwan(CBJPH)
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Jo Ok-Hyun
Choi Chang-Min
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Abstract
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Purpose: It is the purpose of this study to investigate the anti-inflammatory effects and mechanism of cheukbaekjurpihwan(CBJPH) extract on LPS (lipopolysaccharide)-induced inflammatory mediators in murine peritoneal
macrophages.
Methods: To evaluate anti-inflammatory effects of CBJPH extract, the production of cytokines(TNF-α(tumor necrosis factor-alpha), IL(interleukin)-6, IL-12) and NO(nitric oxide) was measured in vitro and in vivo. And western
blot analysis has been done to look into the mechanism.
Results: CBJPH extract reduced LPS-induced NO, TNF-α and IL-6, IL-12 productions in peritoneal macrophages. CBJPH extract inhibited the activation of JNK(c-Jun N-terminal kinase), but didn’t inhibit the activation of MAPKs (mitogen-activated protein kinases) such as p38, ERK1/2(extracelluar signal-regulated kinase1/2) and the degradation of IkB-α(inhibitory kappa B-alpha) in the LPS-stimulated peritoneal macrophages. CBJPH extract suppressed LPS-induced endotoxin shock and the productions of TNF-α, but not of IL-6, after an oral administration of CBJPH extract.
Conclusion: CBJPH extract suppressed the productions of LPS-induced NO and cytokines by preventing JNK from phosphorylation, which may provide a clinical basis for anti-inflammatory properties of CBJPH.
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KEYWORD
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cheukbaekjurpihwan(CBJPH), herbal medicine, LPS, cytokine, inflammation, endotoxin shock
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